Most people, not just women, are familiar with candidiasis. Its symptoms are eloquent and unpleasant, and the causes of its appearance are varied and numerous. Modern pharmacology offers a wide range of drugs used to treat this fungal infection. Pimafucin is often prescribed for thrush, since the drug quickly relieves symptoms and prevents the proliferation of Candida fungi.
Pimafucin is a drug that belongs to the group of fungal antibiotics and has a fungicidal effect. It is considered safe for all age groups of patients, pregnant and lactating women.
The drug is available in several forms, which determine its composition:
- Tablets in a coating that is resistant to gastric juice and dissolves in the intestines. Packaging: bottle, each containing 20 tablets.
- Intervaginal suppositories. Packaging – contour, cell-free, 3 pieces each, 2 packs in a box.
- Cream for topical use on affected areas of the skin. Comes in a 30 ml tube.
In all forms, the active substance is natamycin - it is it that has an antifungal effect.
- potato starch;
- polyvinylpyrrolidone;
- magnesium salt of stearic acid;
- lactose;
- sucrose;
- gelatin;
- methyl p-hydroxybenzoate;
- calcium carbonate;
- cellulose acetate phthalate;
- white beeswax;
- glyceryl triacetate;
- titanium oxide.
Consists of the following excipients:
- cetyl alcohol;
- hard fat;
- sorbitol;
- polysorbitol;
- sodium bicarbonate;
- carboxylic acid.
In addition to natamycin, it contains:
- decyloleate;
- wax;
- cetearyl alcohol;
- sodium dodecyl sulfate;
- preservative E218;
- propyl parahydroxybenzoate;
- propanediol;
- water.
The instructions for use indicate that the product must be stored at temperature conditions no higher than 25 degrees, away from children. The shelf life is 4 years, after which Pimafucin cannot be used for treatment.
How does Pimafucin work?
The active substance of the drug penetrates fungal cells through their membranes and destroys them. The most sensitive to natamycin are fungi of the genus Candida, the pathological reproduction of which leads to thrush.
According to the instructions, Pimafucin does not have any effect on the vital activity of gram-positive or gram-negative microorganisms.
Natamycin - its action
Natamycin does not have a systemic effect, since it is almost not absorbed from gastrointestinal tract, healthy skin and mucous membranes. Enteric-coated tablets release the active ingredients while they are already in the intestines. Progressive biochemical studies confirm the absence of the active substance in the blood and other body fluids of people undergoing Pimafucin therapy.
Pimafucin suppositories turn into foam under the influence of body temperature, which spreads evenly along the walls of the vagina.
The effectiveness of treatment with Pimafucin is expressed in:
- relieving the main symptoms of thrush literally from the first use: itching and heavy discharge;
- relieving swelling in the vagina;
- destruction of fungal cells and spores;
- in pregnant women - improvement in the general condition of the woman and fetus, reduction in tone and the likelihood of premature birth.
When is the drug prescribed?
Instructions for use of the drug Pimafucin contain a list of fungal infections of various organs of the body, which are considered indications for the use of the drug.
Diseases for which it is advisable to use tablets:
- Candidiasis of the mucous surfaces of the oral cavity in acute pseudomembranous and atrophic form, which arose against the background of weakened immunity, including from the use of medications.
- Otomycosis or otitis media of fungal etiology, complicated by the proliferation of pathogenic fungi.
- Candidiasis of the skin and nail plates.
- Inflammatory processes on the glans penis, provoked by the proliferation of Candida fungi.
- Vulvovaginal candidiasis, vulvitis, balanoposthitis.
- As a main and auxiliary remedy for dermatomycosis.
Tablets for the treatment of skin can be used alone, with Pimafucin cream or in combination with other drugs, for example, Griseofulvin.
According to the instructions, diseases of the genital organs are treated with the help of suppositories:
- vaginitis, vulvovaginitis, vulvitis, caused by Candida fungi;
- sometimes - to eliminate pathological discharge and itching in the vagina that is not caused by fungi.
The cream is used for the same indications as the tablets and for the treatment of ulcers that occur in people with diabetes.
According to clinical studies, Pimafucin was effective in all cases of use. The most positive results were achieved in the treatment of vaginitis caused by fungi of the genus Candida.
Use during pregnancy and lactation
The instructions for use indicate that women during pregnancy and breastfeeding are allowed to be treated with Pimafucin for thrush.
Some experts argue that the use of this remedy is necessary in extreme cases, since it is not effective and can aggravate the course of thrush. But such conclusions are based on isolated cases, and the medicine is the most popular in the fight against the disease. Its use is allowed in all three trimesters, without harm to the health of the mother and fetus.
Dosage of the drug according to the instructions
Only a doctor prescribes the drug and its dosage after a comprehensive examination of the patient. The following regimens for use of the drug recommended in the instructions are considered standard:
- The dosage of oral tablets is 4 tablets per day for adults, and 2 for children, throughout the week.
- Pimafucin suppositories are administered 1 per day for 3–6 days. If candidiasis is severe, then treatment with suppositories is supplemented with tablets.
- Local application of the cream is prescribed individually, depending on the brightness and severity of symptoms. On average - from 1 to 4 times a day. If necessary, intensify treatment with tablets.
Method of application indicated in the instructions
Intervaginal administration of suppositories must be carried out at night, in a lying position, so that the product does not leak out and its effectiveness does not decrease due to its smaller amount.
Ringworm most often affects obese people, and foci of inflammation are usually located in the folds, between the phalanges of the fingers, in the groin area and under the mammary glands.
Ulcers in people with diabetes most often form on the feet. When using the cream, it is recommended to continue therapy for another 3-4 days after the symptoms disappear. Otomycosis requires the use of cream up to 4 times a day. The ear canal is first cleaned and, after lubrication, covered with a cotton swab.
On critical days, treatment with Pimafucin is interrupted. If possible, therapy should be started after menstruation.
It is recommended to examine your sexual partner for the presence of a fungal infection. Men are its carriers, but their candidiasis is not so pronounced and is often asymptomatic. But if their thrush is not cured, then the woman will soon have a relapse with a 95% probability.
Sexual intercourse during thrush therapy cannot be ruled out, but barrier contraceptives must be used.
When should you not use Pimafucin?
According to the instructions for use, the drug Pimafucin is contraindicated in the following cases:
- Individual intolerance or hypersensitivity to the components of the drug.
- Patients with intolerance to lactose, fructose and other saccharides contained in the drug.
The drug is used to treat children, starting from newborn age.
The compatibility of the drug with other medications has not been fully studied.
Side effects
Side effects from the use of Pimafucin are extremely rare, and their list given in the instructions is not numerous:
- When taking tablets internally in the first days of therapy, the patient's condition may be accompanied by nausea and stool upset.
- Local application can cause itching and burning of the skin of the genital organs due to cetyl alcohol in the composition of the suppositories.
The drug does not provoke allergic reactions; so far, not a single case has been recorded.
Overdose
Cases of overdose with Pimafucin have not been identified or described, as indicated in the instructions for use of the product.
Drug analogues
One of the few disadvantages of the drug is its high cost. More accessible analogues are:
- Irunin tablets are not much different from Pimafucin in price, are very effective and have virtually no contraindications. The active ingredient is itraconazole.
- Intervaginal suppositories that have the same active substance (Ecofucin, Primafungin).
The new drug Livarol is considered effective, but differs in composition; the main antifungal effect is exerted by ketoconazole. Livarol is prohibited for the treatment of thrush in women during the first trimester of pregnancy.
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Analogs include topical antifungal antibiotic creams:
- Primafungin - available in 20 mg tubes, the active substance is the same as Pimafucin.
- Nystatin ointment - available in 30 mg tubes, the active substance is nystatin.
In addition to Nystatin ointment, release forms in tablets and suppositories are known. Oral use of the drug is contraindicated for children and pregnant women, according to the instructions.
In addition to those listed, accessible analogue is Fluconazole, the price of which starts from 20 rubles. It is available in the form of tablets, capsules and solution for infusion. The active ingredient is fluconazole. Unlike Pimafucin, according to the instructions, it is prohibited to be used to treat children under one year old, and it has a much longer list of contraindications.
Pimafucin is recognized by many gynecologists as the most effective and safe medicine for the treatment of thrush and other fungal diseases. The variety of dosage forms and simplicity of instructions makes its use convenient.
Video: Thrush and how to deal with it
Pimafucin is used to treat thrush in children. This drug has positive reviews not only from medical workers who actively use it in practice, but also from grateful parents who used the drug to treat thrush in their children.
(candidiasis) – infectious disease, provoked by fungi of the genus Candida. Appears in a child on the mucous membranes of the mouth or genitals. In most cases, the disease affects newborns or children in the first year of life. In rare cases, candidiasis can spread to internal organs.
Pimafucin is a widely used antibiotic that has a detrimental effect on most types of yeast fungi, including candida. The main source of infection with candidiasis is the mother of the child, since the woman is the carrier of the disease. Candida lives in the body constantly, but with reduced immunity they begin to actively multiply.
The main causes of illness with thrush or candidiasis may be:
- Failure to comply with hygiene rules when sterilizing bottles, when washing toys, or if the baby’s mother does not clean her breasts before feeding;
- During the passage of a newborn through the birth canal;
- If, when examining a child, medical personnel did not follow the rules of hand hygiene;
- When the body's immunity is reduced;
- Dry mucous membranes of the mouth in an infant;
- Restructuring of hormonal levels;
- Disorders in the gastrointestinal tract;
- As a result of taking antibiotics.
Symptoms of thrush or candidal stomatitis:
- The appearance of a white coating in the mouth, which has a sour odor;
- Curdled spots on the surface of the inner sides of the cheeks, gums, tongue, palate. If you scratch the plaque, then under it there are red inflamed spots, which over time turn into bleeding ulcers (with);
- The baby constantly cries, and when breastfeeding or bottle-feeding, he may refuse to eat because he experiences pain when swallowing;
- Loss of appetite, regurgitation, vomiting, diarrhea.
Instructions for use
The antifungal drug is available in the following forms:
- Pills;
- Vaginal suppositories;
- Cream or ointment (2%) for external use;
- Drops;
- Suspension.
Cream
Pimafucin cream is used for skin candidiasis, or baby diaper rash. The duration of the course is assigned to each child individually. Even if the symptoms have disappeared, the cream is used for several more days.
The cream should be used on fungal-affected areas such as skin and nails 2 to 4 times a day.
Treatment of thrush in girls is also carried out with Pimafucin. The cream is applied to the skin of the genital organs several times a day. The ointment should be used with extreme caution in newborns. If the disease has spread over a large area of skin, then the cream should be applied to small areas. Do not apply ointment to the entire surface of the baby's skin.
Pills
The peculiarity of taking Pimafucin tablet is that it does not penetrate the gastrointestinal tract. This is an advantage over other antibiotics, since they do not cause a huge list of adverse reactions like other drugs. This fact once again confirms the positive reviews about the medicine.
Pimafucin tablets are used for candidiasis of the gastrointestinal tract. They act locally without affecting the gastrointestinal tract.
The tablet shell protects against the influence of gastric juice, which makes it possible to dissolve in the intestines. The dosage depends on the age of the child from 2 to 4 tablets per day, and children of the first year of life may be prescribed part of the tablet. In some cases, suppositories or cream may be prescribed along with the drug.
Drops
For candidiasis of the gums, external mucous membranes of the lips, stomatitis, vulvoginitis, Pimafucin drops are used locally. Reviews about the effectiveness of the drops are positive. Drip at least 4 times a day. The treatment lasts for a week. For stomatitis, drops are most often prescribed.
Candles
The candles are shaped like a torpedo. Pimafucin suppositories are used for vaginal thrush. They contain cetyl alcohol, which causes a burning sensation. Suppositories dissolve in the body due to a reaction to body temperature. Suppositories should be administered before bedtime. Candles are used for 3 to 6 days. This course is quite enough to eliminate thrush.
Features of treatment
Treatment of thrush is carried out in two aspects:
- General therapy is aimed at eliminating conditions conducive to the growth of the fungus;
- Medication to fight candida.
At an appointment with a doctor, you should discuss such issues as the presence of allergies to certain medications, whether certain medications can be used.
During treatment, you need to constantly humidify the air in the room where the child is and spend more time on fresh air which will ensure a speedy recovery. In case of illness it is prescribed proper nutrition, excluding sweets that provoke the spread of fungus. If the baby spits up, you need to change the feeding method.
When a child is infected with candidiasis, a white coating, under which red, inflamed spots can not only bleed, but also be a hotbed for more dangerous infections. This happens with stomatitis.
If the disease is not treated on time, it spreads to the throat, and then to the gums and lips, where cracks form and begin to bleed.
With stomatitis, wounds in the mouth cause such pain to the baby that he cannot swallow and refuses to breastfeed. The baby may develop a fever. In addition, children experience insomnia and become irritable. Immune system worsens and contributes to the occurrence of allergies, as well as serious diseases, including bronchial asthma.
Analogues and price
Pimafucin drug is quite expensive and has no analogues for the active substance. The most similar medicine in terms of spectrum of action is, which is also used to treat thrush on the skin and mouth in babies. You can try cheaper analogues Cloritmazol or Livarol.
Trade name: Pimafucin®
International nonproprietary name: Natamycin
Dosage form: Enteric-coated tablets.
Compound:
1 tablet contains:
Active substance: natamycin 100.0 mg;
excipients: potato starch 79.2 mg, povidone K30 5.0 mg, magnesium stearate 2.5 mg, lactose monohydrate 66 mg;
shell: cellacephate 18 mg, triacetin 2.7 mg, sucrose 122 mg, methyl parahydroxybenzoate 0.07 mg, calcium carbonate 30 mg, kaolin 14.2 mg, talc 21.7 mg, titanium dioxide 3 mg, acacia gum 7.3 mg, gelatin 3.3 mg, white beeswax 0.13 mg.
Description
Round tablets, white or almost white, covered with a shell.
Pharmacotherapeutic group: antifungal agent.
ATX code: A07AA03
Pharmacological properties
Pharmacodynamics
Antifungal polyene (tetraene) antibiotic of the macrolide group. It has a predominantly fungicidal effect. Natamycin irreversibly binds to ergosterol of the cell membrane of the fungal cell, which leads to a violation of its integrity, loss of cytoplasmic contents and cell death. Most pathogenic yeasts and molds are sensitive to natamycin, including the genera Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Dermatophytes and P. boydii are less sensitive to natamycin. Cases of resistance to natamycin in clinical practice not noted. Natamycin in enteric tablet dosage form acts only in the intestinal lumen.
Pharmacokinetics
Natamycin is not absorbed from the gastrointestinal tract and does not have a systemic effect.
Indications for use
Intestinal candidiasis;
- acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
- sanitation of the intestinal reservoir of fungi of the genus Candida for candidiasis of the skin and mucous membranes, incl. for candidiasis vaginitis, vulvitis, vulvovaginitis.
Contraindications
Hypersensitivity to the components of the drug.
Dosage regimen and route of administration
Inside. Eating does not affect the effectiveness of the drug.
For intestinal candidiasis, adults are recommended to take 1 tablet 4 times a day, children - 1 tablet 2 times a day. The average duration of treatment is 1 week.
In case of persistent vaginitis caused by fungi of the genus Candida, Pimafucin® tablets are used together with local antifungal drugs (for example, Pimafucin® suppositories) to sanitize the focus of candidiasis infection in the intestines (1 tablet orally 4 times a day for 10-20 days).
The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.
Precautions for use
Patients with rare congenital intolerance to galactose, fructose, Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase deficiency should take into account that the drug contains lactose monohydrate (66 mg) and sucrose (122 mg).
If you have one of the listed diseases, be sure to consult your doctor before taking Pimafucin®.
Pimafucin® in this dosage form is not recommended for use in infants due to possible difficulty in swallowing tablets.
Drug overdose
There have been no cases of overdose of Pimafucin® reported.
Side effect
From the digestive system: nausea and diarrhea are possible, occurring in the first days of taking the pills and going away on their own during treatment.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Interaction with other drugs
Interaction of the drug Pimafucin® with other medicines not found.
Pregnancy and lactation
The use of the drug Pimafucin® during pregnancy and lactation is possible.
Impact on the ability to drive vehicles and machinery
Pimafucin® does not affect the ability to drive vehicles and machines.
Release form
Enteric-coated tablets 100 mg.
20 tablets in a brown glass bottle, closed with a metal screw cap.
1 bottle in a cardboard box along with instructions for use.
Antifungal drugs of modern modification are highly effective due to their balanced composition; the active substance affects only the affected areas of the skin and mucous membranes, without injuring healthy ones. And among the analogs that are considered the most effective in the treatment of various fungal skin lesions, one should highlight a drug with an antifungal effect and a minimum number of side effects - Pimafucin.
According to the majority of buyers, the use of this drug guarantees a rapid improvement in skin condition, elimination characteristic symptoms damage by fungal infection and stabilization of the regenerative processes of the upper layer of the epidermis. This article will tell you in detail about the instructions for use and analogues of suppositories, tablets, Pimafucin cream, their price and reviews of doctors’ medications.
Features of the drug
The manufacturer guarantees the absence of pronounced negative manifestations when taking this drug. This is due to the rapid penetration of the active substance into the layers of the skin without entering the blood vessels.
With the complex treatment of any fungal skin lesions, the effectiveness of Pimafucin increases, which allows you to obtain the fastest possible positive results even with severe and advanced diseases.
The ease of use is due to the possibility of choosing the dosage form of the drug. Moreover, its effectiveness is independent of the form of release.
A specialist will introduce you to the drug Pimafucin in the video below:
Composition of Pimafucin
The effectiveness of Pimafucin is due to its balanced composition: the active substance is not toxic to the body, therefore the product can be used even with particularly sensitive skin and if the patient has a tendency to.
The composition of Pimafucin is as follows:
- active substance - natamycin (100 mg per tablet);
- auxiliary components - starch, cellulose (acetate phthalate), lactose, magnesium stearate, gelatin, acacia, kaolin, talc, shellac, beeswax.
Each tablet is coated with a yellowish soluble coating. Today, the drug in the form of tablets is in greatest demand in pharmacies: they are easy to use, can be used as an additional type of antifungal therapy, and the effectiveness of administration remains for a long time. A minimal number of side effects when taken and excellent effectiveness are the main characteristics of the drug Pimafucin.
Dosage forms
Pharmacies offer Pimafucin, a remedy against fungal infections, in the form of:
- tablets, coated with a gastrosoluble coating (the tablet contains 100 mg of the active substance, the package contains 20 tablets),
- suppositories for thrush and candidiasis for women (one suppository also contains 100 mg of active ingredient, and one contour cellular packaging contains three suppositories),
- and also in the form of rema Pimafucin and ointments with a similar effect. The cream has a 2% composition (active substance content), is sold in 30 g tubes, and 1 g of cream contains about 20 mg of natamycin.
The cost of each type of drug depends on the size of the selling company’s markup. Thus, Pimafucin tablets are offered for sale at prices from 525 to 558 rubles per pack, vaginal suppositories - from 270 to 530 rubles, depending on the country of origin (the Italian analogue is sold at a slightly lower price, suppositories produced in the Netherlands are offered at a higher cost) . The cream can be found at prices ranging from 358 to 371 rubles per tube.
Pharmacological action
The high degree of effectiveness of using the drug in any dosage form is explained by both the harmony of its composition and the rapid absorption of the drug. At the same time, regardless of the form of the active substance, it does not penetrate into the bloodstream, which determines the absence of a large number of contraindications when using the drug.
Pharmacodynamics
Being a broad-spectrum antifungal agent, Pimafucin has established itself as great option drug therapy for a wide variety of lesions. At the same time, the effectiveness of treatment can be observed both for skin lesions and for diseases internal organs and nails caused by fungal infection.
The effect is based on blocking the sterols of the cell membranes of fungi, which significantly stops the activity of pathogenic microflora. When treatment is carried out for the entire period prescribed by a dermatologist, the vital activity of the fungi completely stops. Works well against mushrooms belonging to the Candida class.
Pharmacokinetics
Susceptibility to the active substance of the drug through the walls of blood vessels does not appear. Absorption of the tablets occurs when they are completely dissolved after entering the gastrointestinal tract. Excretion occurs through urine (through the kidneys) and when it enters the feces (through the intestines).
Read below about the indications for the use of pimafucin for men and women.
Indications
The drug can be used for a significant number of diseases caused by active proliferation of fungi. Pimafucin is most effective on initial stages diseases, but copes well with complex drug therapy and in advanced stages of diseases, as well as in cases of extensive fungal infections.
The drug is prescribed for the following conditions:
- candidiasis of the skin and mucous membranes;
- thrush in women;
- candidiasis of nails;
- ottomycosis (lesions of the middle ear and);
- fungal infections of the upper layer of the epidermis;
- vaginitis;
- vulvitis;
- lesions of the gastrointestinal tract by fungi of the Candida class;
- an increase in the activity of yeast fungi - this is often observed after long-term illnesses, with a sharp decrease in immunity and treatment with antibacterial drugs.
Pimafucin stops the growth of Candida fungus on any part of the body, restores normal microflora and eliminates the unpleasant manifestations of fungal diseases. We will discuss below whether it is possible to use Pimafucin suppositories and tablets during pregnancy.
Instructions for use
Depending on the type of fungal infection, as well as the location of localization, the treatment regimen and the type of dosage form of this drug are used.
- For intestinal candidiasis, the doctor usually prescribes Pimafucin tablets, which are used 4 times a day. The tablet should be taken with plenty of water to dissolve its shell as completely as possible. The duration of taking the drug is at least one week. For children, the dose is reduced - 1/2 tablet.
- In case of candidiasis of the nail plate, a cream should be used as a supplement to the tablets: a small amount of cream is applied to the affected areas several times a day and rubbed into the surface of the nail. The duration of treatment is from 1 to 2.5 weeks, depending on the speed of improvement.
- For thrush, complex treatment is used, based on local administration of vaginal suppositories and taking 1/2 tablet of the drug three times a day. The duration of treatment is 1-3 weeks.
- Also, for women with various types of candidiasis, vaginal suppositories are prescribed before bedtime, which are administered in a lying position. The duration of use is determined by the doctor based on microflora analyses.
- cured with complex treatment with tablets and cream or ointment. The duration of treatment is 2-3 weeks, the tablets are taken 3 times a day, 1 piece, with water.
Contraindications
A contraindication may be an increased degree of sensitivity to the active substance of the drug. Also, indicators under which the period of use of Pimafucin may be limited include the following:
- pregnancy;
- breastfeeding;
- childhood.
However, the treatment regimen should be determined by the attending dermatologist, taking into account individual characteristics and the degree of susceptibility to the active substance.
Side effects
The drug Pimafucin stands out among analogues with antifungal action by a small number of side effects.
- However, with increased individual sensitivity to the components of the product, rashes of varying intensity may occur, accompanied by either. Typically, such manifestations are observed when using a cream or ointment.
- Also, side effects when using Pumaficin include the urge to vomit - such symptoms of the body's immunity to the active substance of the drug appear when using tablets of the drug.
In case of any manifestations of intolerance to Pimafucin, you should stop using it and replace it with a similar drug.
Special instructions
- The use of the drug during pregnancy and breastfeeding is possible, but requires medical supervision and a complete absence of side effects. The active substance does not pass into breast milk.
- In childhood, there is a restriction on the dose of the drug taken: children under 5 years of age are prescribed half the dose of Pimafucin.
Interaction with other drugs
The use of Pimafucin with other antifungal drugs increases the effectiveness of the treatment. Therefore, for extensive lesions of the skin and nails, as well as for advanced ones, comprehensive treatment is recommended.
No negative manifestations were identified when using the drug in question with other broad-spectrum drugs.
Trade name:
Pimafucin ®
International nonproprietary name:
Natamycin
Dosage form:
Enteric-coated tablets.
Compound:
1 tablet contains: Active substance: natamycin 100.0 mg; excipients: potato starch 79.2 mg, povidone K30 5.0 mg, magnesium stearate 2.5 mg, lactose monohydrate 66 mg; shell: cellacephate 18 mg, triacetin 2.7 mg, sucrose 122 mg, methyl parahydroxybenzoate 0.07 mg, calcium carbonate 30 mg, kaolin 14.2 mg, talc 21.7 mg, titanium dioxide 3 mg, acacia gum 7.3 mg, gelatin 3.3 mg, white beeswax 0.13 mg.
Description
Round, white or almost white, film-coated tablets.
Pharmacotherapeutic group:
antifungal agent.
ATX code: A07AA03
Pharmacological properties
Pharmacodynamics
Antifungal polyene (tetraene) antibiotic of the macrolide group. It has a predominantly fungicidal effect. Natamycin irreversibly binds to ergosterol of the cell membrane of the fungal cell, which leads to a violation of its integrity, loss of cytoplasmic contents and cell death.
Most pathogenic yeasts and molds, including genera, are sensitive to natamycin Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Dermatophytes and P. boydii are less sensitive to natamycin. There are no cases of resistance to natamycin in clinical practice. Natamycin in enteric tablet dosage form acts only in the intestinal lumen.
Pharmacokinetics
Natamycin is not absorbed from the gastrointestinal tract and does not have a systemic effect.
Indications for use
- intestinal candidiasis;
- acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
- sanitation of the intestinal reservoir of fungi of the genus Candida for candidiasis of the skin and mucous membranes, incl. for candidiasis vaginitis, vulvitis, vulvovaginitis.
Contraindications
Hypersensitivity to the components of the drug.
Dosage regimen and route of administration
Inside. Eating does not affect the effectiveness of the drug.
For persistent vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (for example, Pimafucin ® suppositories), Pimafucin ® tablets are used to sanitize the focus of candidiasis infection in the intestines (1 tablet orally 4 times a day for 10-20 days).
The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.
Precautions for use
Patients with rare congenital intolerance to galactose, fructose, Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase deficiency should take into account that the drug contains lactose monohydrate (66 mg) and sucrose (122 mg).
If you have one of the listed diseases, be sure to consult your doctor before taking Pimafucin ®.
Pimafucin ® in this dosage form is not recommended for use in infants due to possible difficulty in swallowing tablets.
Drug overdose
No cases of overdose of the drug Pimafucin ® have been reported.
Side effect
From the digestive system: nausea and diarrhea are possible, occurring in the first days of taking the pills and going away on their own during treatment. If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Interaction with other drugs
No interaction of the drug Pimafucin ® with other drugs was detected.
Pregnancy and lactation
The use of the drug Pimafucin ® during pregnancy and lactation is possible.
Impact on the ability to drive vehicles and machinery
Pimafucin ® does not affect the ability to drive vehicles and machines.
Release form
Enteric-coated tablets 100 mg. 20 tablets in a brown glass bottle, closed with a metal screw cap. 1 bottle in a cardboard box along with instructions for use.
Best before date
4 years. Do not use after the expiration date stated on the packaging.
Storage conditions
Store at a temperature not exceeding 25 °C. Keep out of the reach of children.
Conditions for dispensing from pharmacies
Over the counter.
Registration Certificate Holder
LEO Pharma A/S, Denmark Industriparken 55, DK - 2750 Ballerup, Denmark